Details

Autor(en) / Beteiligte

• Artem’eva, O. V.
• Kostomarova, I. V.
• Serova, L. D.

Titel

The clinical and genetic characteristics of long-lived people from the Moscow region

Ist Teil von

• Advances in gerontology, 2014-04, Vol.4 (2), p.95-101

Ort / Verlag

Moscow: Pleiades Publishing

Erscheinungsjahr

2014

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The frequencies of the LPL , CETP , APOE , F 2, F 5, F 7, F 13, FGB , ITGA 2, ITGB 3, PAI -1, MTHFR , MTRR , HLA-DRB 1, HLA-DQA 1, HLA-DQB 1 gene polymorphisms associated with a predisposition to age-related pathologies were analyzed in long-lived people from the Moscow region. The long-lived people were characterized by a favorable course of cardiovascular diseases against the presence of certain genetic factors. Among the latter are the H-H- genotype of the LPL gene and the ɛ2 allele of the APOE gene from the group of genes involved in lipid exchange; the CC genotype of the MTHFR gene (677C > T) from the group of genes regulating the folate cycle; the TC genotype of the ITGB 3 gene and the GA genotype of the FGB gene from the group of genes that are responsible for the coagulation system; and HLA - DRB 1*11 from the group of the major histocompatibility complex genes.