Details

Autor(en) / Beteiligte

• Lam, Maxine SY
• Aw, Joey JY
• Tan, Damien
• Vijayakumar, Ragavi
• Lim, Hui Yi Grace
• Yada, Swathi
• Pang, Qing You
• Barker, Nick
• Tang, Carol
• Ang, Beng Ti
• Sobota, Radoslaw M.
• Pavesi, Andrea

Titel

Unveiling the Influence of Tumor Microenvironment and Spatial Heterogeneity on Temozolomide Resistance in Glioblastoma Using an Advanced Human In Vitro Model of the Blood‐Brain Barrier and Glioblastoma (Small 52/2023)

Ist Teil von

• Small (Weinheim an der Bergstrasse, Germany), 2023-12, Vol.19 (52), p.n/a

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2023

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Microfluidic Models In article number 2302280, Andrea Pavesi and co‐workers develop an in vitro 3D glioblastoma model, that incorporates a perfusable blood‐brain barrier. The model recapitulates key features of clinical disease, such as a diffusive infiltrating tumor front and tumor‐associated dysregulation of vascular permeability. The authors further demonstrate the compatibility with next‐generation ultra‐sensitive mass spectrometry to explore proteins involved in tumorigenesis and drug resistance.