Details

Autor(en) / Beteiligte

• Muheyuddeen, Gulam
• Singh, Swati
• Verma, Stuti
• Kumar Nishchaya
• Tripathi, Subhashish
• Divya, Shishant Rav
• Gupta, Sujeet Kumar

Titel

Synthesis and pharmacological evaluation of aniline derivatives as a potent analgesic and antioxidant agent

Ist Teil von

• NeuroQuantology, 2022-01, Vol.20 (11), p.7040

Ort / Verlag

Bornova Izmir: NeuroQuantology

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• 1, 4- naphthoquinone (Lawsone) is widely distributed in nature and has been used since ancient times in traditional medicine. Lawsone has been used as a dye, and both its natural form and synthetic derivatives exhibit antifungal, antibacterial, antitumor, Antimalarial, molluscicidal, antipsychotic, anticonvulsant, antidepressants, antihypertensive, and Antidiabetic, anti-neurodegenerative andantioxidant activity. 1, 4- naphthoquinone (Lawsone) was isolated from the leaves of Lawsonia inermis by using the pH gradient (agitation) & maceration method. A convenient synthesis of 2-substituted amino naphthalene-1, 4-dione (3a-o) has been achieved by reaction of isolated 1, 4- naphthoquinone with substituted aniline in the presence of ethanol and DPPH model is used for the evaluation of the antioxidant activities and in vivo analgesic activity using albino mice morphine-induced hot plate method. The structure of the ultimate analogs has been inveterate on the basis of elemental analysis, IR, 1H NMR, mass spectra and elemental analysis. All the standards of elemental investigation, IR, 1H NMR, and mass spectra were initiate to be prominent. The results indicate that synthesized compound 3d having IC50 75.39 ± 4.12 mg/ml showed potent antioxidant activity comparable to standard ascorbic acid (IC50 45.54 ± 3.06 mg/ml). 3c, 3m, and 3o showed potent analgesic activity comparable to standard nimesulide (100% at 50 mg/kg b.w). This reading suggests that leaves of Lawsonia inermis have bioactive compounds for innovative antioxidant & analgesic remedy development