Details

Autor(en) / Beteiligte

• Ozyurt, Aylin Balci
• Reçber, Tuba
• Nemutlu, Emirhan
• Bulus, Ayse Derya
• Sedef Kir, Sedef
• Kocer-Gumusel, Belma
• Erkekoglu, Pinar

Titel

Metabolomic Studies in Girls With Central and Peripheral Precocious Puberty

Ist Teil von

• FABAD journal of pharmaceutical sciences, 2023-10, Vol.48 (3), p.523-538

Ort / Verlag

Ankara: Hacettepe University Faculty of Medicine

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [...]growth rate, somatic development, and skeletal maturation increase (Kiess et al, 2016). Each biological specimen has its own metabolomic profile even collected from same individual, and these differences can be used for identifying a biomarker. [...]to obtain a more comprehensive profile, different biological specimens from one individual must be used (Zeki et al, 2020). Breast development before the age of eight, pubic, and/or axillary hair growth, bone age 1 year older than the calendar age, body mass index (BMI) between 25-85% according to age, and gender, peak luteinizing hormone (LH) in GnRH stimulation test response above 5 mlU/mL, and routine pituitary MR imaging were the diagnostic criteria. Collection, and storage of biological material Blood, and spot urine samples taken from the CPP, and PPP patients, and healthy volunteers in the Kecioren Training, and Research Hospital, Clinic of Pediatric Endocrinology were brought to the Hacettepe University Faculty of Pharmacy Pharmaceutical Toxicology Laboratory on dry ice.