Details

Autor(en) / Beteiligte

• Tripathi, Ruchita
• Ranjan, Amit
• Pratap, Raghvendra
• Singh, Anil Kumar
• Singh, Rajesh Kumar

Titel

Panchvalkal (an Ayurvedic Formulation) Proliferates Pancreatic β-Cells and Increases the Potency of Conventional drug Glibenclamide

Ist Teil von

• National Academy of Sciences, India. Proceedings. Section B. Biological Sciences, 2023-12, Vol.93 (4), p.1015-1025

Ort / Verlag

New Delhi: Springer India

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Diabetes is a common metabolic syndrome in Indian population. The drugs used for its management based on enzyme and hormone. The development of resistance against conventional drugs in diabetic patients is a major challenge for clinicians to treat the patients effectively. Panchavalkala is a polyherbal formulation, described in Ayurveda for management of many clinical ailments and potentiating the antibacterial drugs in recent studies. In this study it has been evaluated for integration with conventional drug, Glibenclamide for potentiating the efficacy and safety for management of patient with diabetes mellitus in north Indian population. The methodology of Panchvalkala kwath preparation is according to protocol described in Ayurvedic Pharmacopoiea of India (API) and evaluated for safety and efficacy alone and integrated with conventional drug, Glibenclamide in in vitro as well as in-vivo model. The waster rats as used as in-vivo model with Streptozotocin diabetes induction. The results show that the integration of the Ayurvedic formulation is safe and potentiating the efficacy of Glibenclamide.