Details

Autor(en) / Beteiligte

• Zhang, Xue
• Mo, Jian
• Da-Shuang, Luo
• Xue-Min Niu
• Hai-Feng, Yu
• Xiao-Bo, Zhao

Titel

Facile synthesis of 3-(pyrazol-1-yl) succinimides from Ag2CO3 -catalyzed aza-Michael addition of pyrazoles to maleimides

Ist Teil von

• Synthetic communications, 2023-12, Vol.53 (24), p.2088-2096

Ort / Verlag

Philadelphia: Taylor & Francis Ltd

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Herein, an effective and facile synthesis of 3-(pyrazol-1-yl) succinimides is first presented through silver-catalyzed aza-Michael addition of pyrazoles to maleimides. In the presence of 5 mol% of Ag2CO3, various pyrazoles smoothly reacted with maleimides in dichloroethane at 100 °C, to generate 3-(pyrazol-1-yl) succinimides in excellent yields. Notably, 3-substituted asymmetric pyrazoles exclusively give 3-pyrazolyl succinimides in excellent yields possibly due to the steric bulk of the 3-substituent excluding the formation of addition products of N2. The method can also extend to gram scale.