Details

Autor(en) / Beteiligte

• Zhang, Yin
• Bao, An‐Qi
• Wu, Ming
• Rao, Qian
• Tu, Man‐Su
• Hao, Wen‐Juan
• Jiang, Bo

Titel

Regioselective Construction of Indolylated Cyclic Tetrasubstituted Carbon Centers through Brønsted Acid‐Catalyzed Dearomative Skeletal Rearrangement of Azofurans

Ist Teil von

• Advanced synthesis & catalysis, 2023-11, Vol.365 (21), p.3718-3723

Ort / Verlag

Heidelberg: Wiley Subscription Services, Inc

Erscheinungsjahr

2023

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Abstract A Brønsted acid‐catalyzed dearomative skeletal rearrangement of azofurans with indoles is reported, enabling a regioselective 1,6‐addition, ring‐opening and 1,4‐addition cascade to produce 26 examples of indolylated pyrrol‐2‐ones with a cyclic tetrasubstituted stereocenter in 58–94% yields. This protocol demonstrates remarkable compatibility regarding azofurans and indoles with different substitution patterns, featuring complete regioselectivity.