Details

Autor(en) / Beteiligte

• Lou, Tong
• Bai, Xiuqin
• He, Xiaoyan
• Liu, Wencheng
• Yang, Zongcheng
• Yang, Ying
• Yuan, Chengqing

Titel

Antifouling performance of d-enantiomers-based peptide-modified aluminum alloy surfaces with enhanced stability against proteolytic degradation

Ist Teil von

• Journal of materials science, 2023-10, Vol.58 (39), p.15499-15512

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Marine biofouling presents a significant challenge to the sustainable development of the maritime industry. Antimicrobial peptide (AMP) offers a promising strategy to combat biofouling. However, the inherent susceptibility of natural AMPs composed of L -amino acids to proteolytic degradation limits their practical application. This study investigated the stability of peptides containing d -amino acids against proteolytic degradation and evaluated their antifouling performance through the modification of aluminum-based surfaces with these peptides. d -peptides exhibited remarkable stability compared to the l -peptides counterpart when exposed to pepsin. Furthermore, the surfaces modified with d -peptides displayed excellent antifouling capacity by significantly inhibiting the adhesion of Bacillus sp. (58.6%) and E. coli (88.7%), the comparable effects observed with l -peptides (61.7%) and (87.5%), respectively. Coarse-grained molecular dynamics simulations and scanning electron microscopy results analyses revealed that immobilized d -peptides effectively disrupted bacterial cell membranes, thereby preventing bacterial adhesion. This research provided a viable approach to enhance the stability of peptides against proteolytic degradation while maintaining outstanding antifouling performance, contributing to the development of effective strategies for antifouling in the maritime industry. Graphical Abstract