Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Electrochemical N -acylation and N -α-ketoacylation of sulfoximines via the selective decarboxylation and dehydration of α-ketoacids
Ist Teil von
Green chemistry : an international journal and green chemistry resource : GC, 2023-10, Vol.25 (21), p.8838-8844
Ort / Verlag
Cambridge: Royal Society of Chemistry
Erscheinungsjahr
2023
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Sulfoximines are commonly found in pharmaceuticals, agrochemicals and other biologically active compounds. However, limited reports exist for their selective functionalization
via
green and efficient protocols. Herein, we describe an electrochemical
N
-acylation and
N
-α-ketoacylation of sulfoximines
via
the selective decarboxylation and dehydration of α-ketoacids. These two reactions use electricity as a “traceless” oxidant and α-ketoacid as a selective “acyl” or “α-ketoacyl” source. A broad range of acylated- and α-ketoacylated sulfoximines were isolated in good to excellent yields (up to 88% and 96% yields). Moreover, these protocols have also been applied to late-stage derivatizations of fenofibrate and can be safely conducted on a gram scale.