Details

Autor(en) / Beteiligte

• G, Spoorthi

Titel

To Study Clinical Profile of Malaria with Reference to Hepatopathy

Ort / Verlag

ProQuest Dissertations & Theses

Erscheinungsjahr

2018

Quelle

ProQuest Dissertations & Theses A&I

Beschreibungen/Notizen

• Introduction :Malaria is an infectious disease caused by protozoan parasites from the Plasmodium family. The liver has a major role in the life cycle of the malaria parasite and is seriously affected in some cases. Malarial hepatitis” or “Malarial hepatopathy” is characterised by hyperbilirubinemia (>3mg/dl) and elevated transaminase enzymes of up to more than three times the normal level. The study aimed to study the complications of malaria in patients with malarial hepatopathy compared to patients without hepatopathy.Materials and methods :This study was conducted in Navodaya Medical college and Hospital, Raichur .This is a case control study with 60 patients with malaria of which 30 patients were cases with malarial hepatopathy and 30 patients were controls with normal liver enzymes. All adult patients presenting with fever who tested positive for malaria in peripheral smear were enrolled in the study of both sexes and different age groups. Investigations like thick and thin blood smear, QBC, complete hemogram, liver function tests, renal function tests and random blood sugar were done in all patients.Results :In our study the incidence of malaria was more in males compared to females. Majority of the patients with malarial hepatopathy suffered from falciparum malaria. The most common presenting complaint was fever with chills and rigors in both cases and controls (100%). Other symptoms were headache (33.3% vs 13.3%), bodycahe (26.6% vs 10.0%), vomiting (23.3% vs 6.7%), breathlessness (13.3% vs 3.3%), oliguria (26.6% vs 10.0%) and altered bowel habits (13.3% vs 3.3%) in the cases and controls respectively. All cases with malarial hepatopathy had icterus. Pallor (53.3% vs 30.0%) and oliguria ( 26.6% vs 10.0%) was more in the case group compared to the control group whereas bleeding manifestations was seen only in the case group with 13.3%. Hepatomegaly and Splenomegaly was more in cases compared to controls. Complications like renal dysfunction, severe anemia, cerebral malaria, hypotension and hypoglycemia were seen more in the case group compared to the control group.Conclusion:Presence of hepatopathy indicates more severe illness with higher complications and poor prognosis.