Details

Autor(en) / Beteiligte

• Gibney, Alex
• de Paiva, Raphael E. F.
• Singh, Vandana
• Fox, Robert
• Thompson, Damien
• Hennessy, Joseph
• Slator, Creina
• McKenzie, Christine J.
• Johansson, Pegah
• McKee, Vickie
• Westerlund, Fredrik
• Kellett, Andrew

Titel

Back Cover: A Click Chemistry‐Based Artificial Metallo‐Nuclease (Angew. Chem. Int. Ed. 38/2023)

Ist Teil von

• Angewandte Chemie International Edition, 2023-09, Vol.62 (38)

Auflage

International ed. in English

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A new click chemistry generated artificial metallonuclease is reported in the Research Article by Andrew Kellett et al. (e202305759). The oxidative DNA damaging properties of a polynuclear copper binding ligand called TC‐Thio is demonstrated. Copper‐TC‐Thio binds in the minor groove of genomic DNA and promotes damage via a superoxide linked mechanism. The inset picture shows copper ions, bound to the TC‐Thio ligand, melting into the DNA duplex and filling the reaction chamber with molten liquid DNA.