Details

Autor(en) / Beteiligte

• Nisa, S. Amreen
• Govindaraju, K.
• Vasantharaja, R.
• Kannan, M.
• Raja, K.

Titel

Jellyfish Acromitus flagellatus (Maas) nematocyst venom-mediated biogenic synthesis of gold nanoparticles and its anti-proliferative effects

Ist Teil von

• Aquaculture international, 2023-08, Vol.31 (4), p.2235-2244

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2023

Quelle

SpringerLink

Beschreibungen/Notizen

•   The present study examines the biogenic preparation of gold nanoparticles using jellyfish Acromitus flagellatus ( A. flagellatus ) nematocyst venom and their anti-proliferative studies in HEK-293 (normal) and MCF-7 (cancer) cell lines. The nematocyst venom-mediated biogenic prepared gold nanoparticles were characterized using UV–Vis spectroscopy, X-ray diffraction (XRD) and transmission electron microscopy (TEM). TEM micrographs showed that biosynthesized gold nanoparticles possess spherical and triangle morphology with size ranges of about 12–53 and 173–217 nm, respectively. Furthermore, the MTT assay was performed to investigate the anti-proliferative effect of nematocyst venom and nematocyst venom-mediated biogenic gold nanoparticles. The results reported that the nematocyst venom-mediated biogenic gold nanoparticles reduced the cell proliferation in cancer cells MCF-7 with an IC 50 of 45.65 μg mL −1 and 18.24 μg mL −1 compared to normal cells (HEK-293) at 48 h. These findings indicated that gold nanoparticles with venom residue exert their anti-proliferative action on the MCF-7 cell line. Graphical Abstract