Details

Autor(en) / Beteiligte

• Chun-Mei, Luo
• Yong-Bin, Sun
• Ling-Tao, Wang
• Nan-Nan Dai
• Jiao-Zhe, Li
• Zhang, Jianfeng
• Jin-Yang, Chen
• Wen-Ting, Wei
• Guo-Ping, Ge

Titel

Copper-catalyzed multicomponent cascade synthesis of polyfunctionalized β-ketone sulfones

Ist Teil von

• Organic chemistry frontiers an international journal of organic chemistry, 2023-08, Vol.10 (16), p.4023-4029

Ort / Verlag

London: Royal Society of Chemistry

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The multicomponent cascade reaction provides an efficient paradigm for the preparation of complex compounds in synthetic chemistry. Herein, we describe a copper-catalyzed multicomponent cascade reaction of vinyl azides and oxime esters with SO2 sources for the synthesis of polyfunctionalized (aryl-, alkyl-) β-ketone sulfones. This protocol exhibits high step economy and excellent selectivity, and the target products can be produced in good yields with a low-cost copper catalyst under mild reaction conditions. Four new chemical bonds are formed in one pot through a series of processes including radical relay, radical addition, hydrogen abstraction, hydrolysis or oxidation. The gram-scale and four-component cascade reactions related to initial feedstocks of vinyl azides highlight the practicality and efficiency of this method.