Details

Autor(en) / Beteiligte

• Merzlikin, G. V.
• Akulinichev, S. V.
• Yakovlev, I. A.

Titel

Simulation of a Proton Beam Facility in the TOPAS MC Software Package

Ist Teil von

• Moscow University physics bulletin, 2023-02, Vol.78 (1), p.21-26

Ort / Verlag

Moscow: Pleiades Publishing

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The aim of the work is to simulate the passive scattering system for the therapeutic proton beams on the accelerator at the Institute for Nuclear Research, Russian Academy of Sciences, using the TOPAS MC software package and to calculate the characteristics of irradiation of biological objects. As a characteristic of assessing the dependence of the absorbed dose and linear energy transfer (LET) on the range of protons in water and the biologically effective dose (BED) of irradiation of HT-29 and HCT-116 cell lines used in real experiments. Also, the uniformity of irradiation with a high dose rate of the studied biological objects in case of FLASH-therapy modes irradiation was evaluated. The research is aimed at preparing and carrying out radiobiological experiments with proton beams with a record high dose rate.