Details

Autor(en) / Beteiligte

• Lee, Hochan
• Joo, Jeong‐Un
• Dhamija, Avinash
• Gunnam, Anilkumar
• Koo, Jaehyoung
• Giri, Pritam
• Ho Ko, Young
• Hwang, In‐Chul
• Kim, Dong‐Pyo
• Kim, Kimoon

Titel

Flow Synthesis of Gigantic Porphyrinic Cages: Facile Synthesis of P12L24 and Discovery of Kinetic Product P9L18

Ist Teil von

• Chemistry : a European journal, 2023-06, Vol.29 (34), p.n/a

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2023

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• A continuous flow methodology for the facile and high‐yielding synthesis of the porphyrin‐based self‐assembled organic cage, P12L24 is reported, along with the serendipitous discovery of a kinetic product, P9L18 cage, which has been characterized by MALDI‐TOF MS, NMR, and AFM analysis. A theoretical study suggests a tricapped trigonal prismatic geometry for P9L18. Unlike P12L24, P9L18 is unstable and readily decomposes into monomers and small oligomers. While the batch synthesis produces only the thermodynamic product P12L24, the continuous flow process generates not only the thermodynamic product but also kinetic products, such as P9L18, illustrating the advantages of the continuous flow process for the synthesis of self‐assembled cages and the exploration of new non‐equilibrium assemblies. Herein, we report continuous flow synthesis of gigantic porphyrinic cages by microfluidic approach. The flow synthesis not only increases the yield of P12L24 but also significantly reduces the reaction times. Moreover, we discover a kinetic product P9L18 by varying reaction conditions.