Details

Autor(en) / Beteiligte

• Lukovenkov, A. V.
• Bykov, V. I.
• Varfolomeev, S. D.

Titel

Kinetic Features of Elongation of Nucleic Acids as a Multistep Sequential Enzymatic Reaction

Ist Teil von

• Kinetics and catalysis, 2023-04, Vol.64 (2), p.161-167

Ort / Verlag

Moscow: Pleiades Publishing

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The kinetics of elongation of nucleic acids as a multistep sequential reaction forming a cycle was studied. A mathematically rigorous proof was given for the empirical formulas used to estimate the elongation time as a function of the length of the nucleotide chain. Estimates of the characteristic elongation time for typical chain lengths were proposed, including for the novel coronavirus (SARS-CoV-2). The stability of the elongation kinetics was investigated, and it was determined that, at typical chain lengths, increasing-amplitude unstable oscillating components appear along with the main exponential component.