Details

Autor(en) / Beteiligte

• Al-Rawahi, Ahmed N.
• Abed, Raeid M. M.
• Rehman, Najeeb Ur
• Rafiq, Kashif
• Khan, Ajmal
• Khan, Abdul L.
• Khan, Majid
• Halim, Sobia Ahsan
• Al-Senafi, Fahad
• Mahmoud, Huda
• Al-Harrasi, Ahmed

Titel

New Sulfur-Containing Diketopiperazine from Marine-Derived Bacteria Streptomyces rochei sp. 81 with Potent Carbonic Anhydrase II Inhibition

Ist Teil von

• Chemistry of natural compounds, 2023-03, Vol.59 (2), p.346-350

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The ethyl acetate extract of the marine bacterial strain Streptomyces rochei sp. 81 was purified by silica gel column chromatography to obtain three diketopiperazines ( 1–3 ) and one straight chain fatty acid ( 4 ). The compounds were identified as cyclo(L-leu- N -ethenethiol-L-pro) ( 1 ), cyclo(L-Leu-L-Pro) ( 2 ), cyclo(L-Pro-D-Tyr) ( 3 ), and 2,4-dimethyldocasonoic acid ( 4 ) by HR-ESI-MS and NMR techniques. One new ( 1 ) and three known compounds ( 2 – 4 ) were screened for carbonic anhydrase-II (CA-II) inhibition and as a result 1 and 3 were found to be the most active compounds with IC 50 of 9.8 ± 0.56 and 10.9 ± 0.88 μM, respectively. The results indicated that these two compounds ( 1 and 3 ) can be promising candidates for anticancer drugs.