Details

Autor(en) / Beteiligte

• Wen, Zhong
• Yang, Kai‐Cheng
• Deng, Jun‐Feng
• Chen, Long

Titel

Advancements in the Preparation of 4H‐Chromenes: An Overview

Ist Teil von

• Advanced synthesis & catalysis, 2023-05, Vol.365 (9), p.1290-1331

Ort / Verlag

Heidelberg: Wiley Subscription Services, Inc

Erscheinungsjahr

2023

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Functionalized 4H‐chromenes represent one class of the most important structural scaffolds in both synthetic and medicinal chemistry. They often appear in an arrange of biological natural products, pharmaceutical agents and drug candidates. The significance has stimulated the development of efficient methodologies for the synthesis of such compounds. In this review, a comprehensive discussion on different synthetic approaches to 4H‐chromenes has been presented with an emphasis on reaction features and mechanisms. Three main categories are outlined: 1) nucleophilic addition to 2H‐chromene derivatives, 2) 4H‐chromene ring formation involved cycloaddition or cyclization reactions, and 3) miscellaneous reactions.