Details

Autor(en) / Beteiligte

• Erdelyi, K. E.
• Antonets, A. A.
• Zhidkova, O. B.
• Druzina, A. A.
• Nazarov, A. A.
• Timofeev, S. V.
• Sivaev, I. B.
• Bregadze, V. I.

Titel

Cobalt and iron bis(dicarbollide) conjugates with cholesterol: synthesis and evaluation of antiproliferative activity

Ist Teil von

• Russian chemical bulletin, 2023-04, Vol.72 (4), p.1059-1065

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2023

Quelle

SpringerLink Journals (MCLS)

Beschreibungen/Notizen

• Boron-containing conjugates of cholesterol were synthesized by the copper( i )-catalyzed 1,3-dipolar [3+2] cycloaddition reactions of cobalt and iron bis(dicarbollide) azide derivatives with alkynyl cholesterol. The antiproliferative activity (IC 50 ) of the conjugates was evaluated against a series of human cell lines by the MTT assay. All conjugates were shown to be nontoxic (IC 50 >200 µmol L −1 ) and to be applicable for the preparation of boron-containing liposomes as potential drugs for boron-neutron capture therapy (BNCT) of cancer.