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Cobalt and iron bis(dicarbollide) conjugates with cholesterol: synthesis and evaluation of antiproliferative activity
Ist Teil von
Russian chemical bulletin, 2023-04, Vol.72 (4), p.1059-1065
Ort / Verlag
New York: Springer US
Erscheinungsjahr
2023
Quelle
SpringerLink Journals (MCLS)
Beschreibungen/Notizen
Boron-containing conjugates of cholesterol were synthesized by the copper(
i
)-catalyzed 1,3-dipolar [3+2] cycloaddition reactions of cobalt and iron bis(dicarbollide) azide derivatives with alkynyl cholesterol. The antiproliferative activity (IC
50
) of the conjugates was evaluated against a series of human cell lines by the MTT assay. All conjugates were shown to be nontoxic (IC
50
>200 µmol L
−1
) and to be applicable for the preparation of boron-containing liposomes as potential drugs for boron-neutron capture therapy (BNCT) of cancer.