Details

Autor(en) / Beteiligte

• Nurjadi, Dennis
• Klein, Sabrina
• Zimmermann, Stefan
• Heeg, Klaus
• Zanger, Philipp

Titel

Transmission of ST8-USA300 Latin American Variant Methicillin-Resistant Staphylococcus aureus on a Neonatal Intensive Care Unit: Recurrent Skin and Soft- Tissue Infections as a Marker for Epidemic Community-Associated-MRSA Colonization

Ist Teil von

• Infection control and hospital epidemiology, 2017-07, Vol.38 (7), p.883-885

Ort / Verlag

United States: Cambridge University Press

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• USA300 is the predominant MRSA clone circulating in the community in the United States, and it is recognized as a common cause of nosocomial S. aureus bloodstream infections, increasingly blurring the classic distinction between community- and hospital-associated MRSA.1 A variant of this virulent strain, designated as the Latin American Variant of USA300 MRSA (USA300-LV), was able to infiltrate, disseminate, and become the predominant MRSA in the community as well as in healthcare settings across most of Latin America.2 Although international travel and migration fosters the global spread of S. aureus,3,4 detection of USA300-LV in Europe is rare1,3 and generally occurs in subjects with close family or travel links to Latin America.3 Nevertheless, the first observations of its autochthonous spread in the community have been reported in Spain and Italy.1 To date, in-hospital transmission of USA300-LV is an entirely unknown phenomenon in Europe, in contrast to Latin America, where it accounts for a substantial proportion of the nosocomial MRSA infections in Columbia and Uruguay.1,2 In October 2016, preoperative screening revealed Panton-Valentine leucocidin–positive (PVL+) MRSA isolated from a nasal swab of a 16-day-old, premature newborn (gestational age 33 weeks 2 days; 1,360 g) that had been hospitalized since birth due to a congenital heart anomaly (index case) (Table 1). [...]to increase the sensitivity of CA-MRSA detection in the future, we propose targeted screening of all patients reporting recurrent SSTI defined as 2 or more episodes within the last 12 months in either (1) themselves or (2) members of the same household. [...]European surveillance activities must address the silent invasion by USA300-LV and must monitor the import and spread of ACME-neg, MLST 8, SCCmec IVc MRSA.