Details

Autor(en) / Beteiligte

• Pérez-Rafael, Sílvia
• Pagani, Ayelen
• Palacios, Òscar
• Dallinger, Reinhard
• Capdevila, Mercè
• Atrian, Sílvia

Titel

The Role of Histidine in a Copper-Specific Metallothionein

Ist Teil von

• Zeitschrift für anorganische und allgemeine Chemie (1950), 2013-07, Vol.639 (8-9), p.1356-1360

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2013

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Metallothioneins achieve metal binding specificity by modulation of their amino acid sequences through evolution. Non‐coordinating residues seem to play a key role in this function, and among them histidine may be of particular importance. Here we report how this residue regulates CuI binding to a highly copper specific isoform, the CuMT of the snail Helix pomatia, by analysis of the recombinant complexes yielded by a constructed mutant where this residue has been changed to an alanine.