Details

Autor(en) / Beteiligte

• Thuy, Bui Thi Phuong
• Hieu, Le Trung
• My, Tran Thi Ai
• Hai, Nguyen Thi Thanh
• Loan, Huynh Thi Phuong
• Thuy, Nguyen Thi Thu
• Triet, Nguyen Thanh
• Van Anh, Tran Thi
• Dieu, Nguyen Thi Xuan
• Quy, Phan Tu
• Van Trung, Nguyen
• Quang, Duong Tuan
• Huynh, Lam K.
• Nhung, Nguyen Thi Ai

Titel

Screening for Streptococcus pyogenes antibacterial and Candida albicans antifungal bioactivities of organic compounds in natural essential oils of Piper betle L., Cleistocalyx operculatus L. and Ageratum conyzoides L

Ist Teil von

• Chemical papers, 2021-04, Vol.75 (4), p.1507-1519

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Chemical composition and bioactivities including bacterial and fungal resistance of the essential oils extracted from leaves of Piper betle L. ( T ) and Cleistocalyx operculatus L. ( V ) and aerial parts of Ageratum conyzoides L. ( H ) were investigated. The components presenting in the essential oils of the natural sources were analysized by a gas chromatography–mass spectrometry. Molecular docking simulation was utilised to support an antimicrobial mechanism of the essential oil compounds on Candida albicans fungus and Streptococcus pyogenes bacteria. This was based on the inhibition of the extracted compounds onto the microbial proteins, i.e. 4ESW and P0C0C7, respectively. There are 32 compounds identified in total in the three essential oils. The most effective inhibitors are the following: (i) chavicol acetate ( T3 ), eugenol acetate ( T11 ) and eugenol ( T4 ) found in Piper betle L.; (ii) precocene II ( H10 ) and precocene I ( H6 ) found in Ageratum conyzoides L.; and (iii) caryophyllene oxide ( V15 ) and cis -Lanceol ( V19 ) found in Cleistocalyx operculatus L.. The overall antifungal and antibacterial capability of the investigated essential oils given indirect justification via their average inhabitability towards the two proteins accords with the order Piper betle L. Ageratum conyzoides L. Cleistocalyx operculatus L.. The results suggest these as promising natural sources for antimicrobial remedies.