Details

Autor(en) / Beteiligte

• Romero-González, M
• Cordero Ramos, J
• Valera Rubio, M
• Merino Bohorquez, V
• Martin Casado, L

Titel

6ER-024 Comparison of reductions in monthly migraine days between new small molecule cgrp receptor antagonists (gepants) and monoclonal antibodies targeting cgrp/cgrp receptor

Ist Teil von

• European journal of hospital pharmacy. Science and practice, 2023-03, Vol.30 (Suppl 1), p.A166-A166

Ort / Verlag

London: British Medical Journal Publishing Group

Erscheinungsjahr

2023

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Background and ImportanceMigraine is characterised by repeated headache attacks lasting hours or days and usually accompanied by other associated symptoms. According to the International Headache Society, it can be classified into migraine with aura, without aura and chronic migraine. A target pathway to treat or prevent migraine is the calcitonin gene-related peptide. Available treatments in our country that act interfering that pathway are erenumab, fremanezumab, galcanezumab, iptenezumab and rimegepant.Aim and ObjectivesTo analyse whether the different therapeutic options are equivalent alternatives through an adjusted indirect comparison.Material and MethodsThe therapies included were found after a systematic search performed in PubMed. The analysis included randomised, double-blind, phase 2 and 3, controlled trials, prophylaxis therapies and number of migraine days reduced measurement after 12 weeks of treatment. The analysis was performed using the R® software to estimate Bayesian statistics, with rimegepant taken as a reference for the comparison. A delta value of 1 day, as provided by the regulatory agencies FDA and EMA, was used to determine the margin (maximum acceptable difference as a non-inferiority criteria) and the average number of migraine days reduced. To establish the therapeutic positioning, the National Equivalent Therapeutic Alternatives Positioning Guide criteria were applied.ResultsAs shown in Figure 1, the difference in the mean number of migraine days reduced per month versus placebo was favourable in all cases. Each treatment reduced migraine by between one to two days per month, showing statistically significant differences. The most outstanding being fremanezumab (-1,73 [-2.33;-1.12]). Based on the results obtained, a subsequent analysis was carried out comparing fremanezumab with the other alternatives. In this case, erenumab 140 mg showed the most similar efficacy result (0.13 [-1.14; 1.39]). Nevertheless, it did not show a statistically significant difference against any treatment, exclusively against placebo. No differences were found in terms of safety.Abstract 6ER-024 Figure 1Forest-plot of the decrease in average number of migraine days per month. Comparator: rimegepant 75mg/48h. SMD: standard mean difference. 95% CI: 95% confidence intervalConclusion and RelevanceNo statistically significant differences were found between rimegepant and monoclonal antibodies against the CGRP/CGRP receptor except for fremanezumab. Fremanezumab presented a statistically significant more pronounced response in the decrease of migraine days per month at 12 weeks of treatment.References and/or AcknowledgementsConflict of InterestNo conflict of interest