Details

Autor(en) / Beteiligte

• Hou, Yang-Yang
• Xu, Jing
• Xie, Wan-Zhen
• Huang, Ke-Jing
• Tan, Xuecai
• Zhao, Bing-Rui
• Zhang, Si-Qi
• Gao, Meng-Tian

Titel

3D DNA walker recognition-driven homogeneous dual-mode sensing strategy based on enzyme biofuel cell for ultrasensitive detection of HER2

Ist Teil von

• Sensors and actuators. B, Chemical, 2023-02, Vol.376, p.132998, Article 132998

Ort / Verlag

Lausanne: Elsevier B.V

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An ultrasensitive enzyme biofuel cell (EBFC) based self-powered biosensor is developed for electrochemical/colorimetric dual-mode detection of human epidermal growth factor receptor 2 (HER2). Graphdiyne (GDY) and tetragonal molybdenum disulfide (1 T MoS2) are prepared to construct high-performance EBFC. Three-dimensional (3D) DNA Walker triggers hybrid chain reaction (HCR) cascade strategy is used to further improve the output signal intensity and selectivity of assay. Furthermore, a capacitor is matched to EBFC to generate electrical signals magnified several times for boosting the analytical performance. An ultrasensitive dual-mode assay is therefore developed for HER2 with an expanded linear response range of 0.1–10000 pg/mL and a low detection limit of 0.03 pg/mL (S/N = 3). The results confirm the developed assay provides a powerful tool for ultrasensitive and accurate detection of cancer marker. •An ultrasensitive self-powered biosensor is developed for dual-mode detection of HER2.•Graphdiyne and 1 T metal phase molybdenum disulfide are prepared to construct high-performance EBFC.•DNA walker triggers hybrid chain reaction cascade strategy further greatly improve the sensitivity.•Capacitor is used to amplify output signal for boosting analytical performance.