Details

Autor(en) / Beteiligte

• Thangam, Ramar
• Kim, Seong Yeol
• Kang, Nayeon
• Hong, Hyunsik
• Lee, Hyun‐Jeong
• Lee, Sungkyu
• Jeong, Daun
• Tag, Kyong‐Ryol
• Kim, Kanghyeon
• Zhu, Yangzhi
• Sun, Wujin
• Kim, Han‐Jun
• Cho, Seung‐Woo
• Ahn, Jae‐Pyoung
• Jang, Woo Young
• Kim, Jong Seung
• Paulmurugan, Ramasamy
• Khademhosseini, Ali
• Kim, Hong‐Kyu
• Kang, Heemin

Titel

Ligand Coupling and Decoupling Modulates Stem Cell Fate

Ist Teil von

• Advanced functional materials, 2023-02, Vol.33 (8), p.n/a

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc

Erscheinungsjahr

2023

Quelle

Wiley-Blackwell Full Collection

Beschreibungen/Notizen

• In natural microenvironment, various proteins containing adhesive ligands in fibrous and non‐fibrous structures dynamically couple and decouple to regulate stem cell fate. Herein, materials presenting movably couplable ligands are developed by grafting liganded gold nanoparticles (AuNPs) to a substrate followed by flexibly grafting liganded movable linear nanomaterials (MLNs) to the substrate via a long bendable linker, thereby creating a space between the MLNs and the AuNPs in the decoupled state. Magnetic control of the MLNs decreases this space via the bending of the linker to couple the MLNs to the AuNPs. Remote control of ligand coupling stimulates integrin recruitment to the coupled ligands, thereby non‐toxically facilitating the focal adhesion, mechanosensing, and potential differentiation of stem cells, which is suppressed by ligand decoupling. Versatile tuning of size, aspect ratio, distributions, and ligands of the MLNs can help to decipher dynamic ligand‐coupling‐dependent stem cell fate to advance regenerative therapies. The control of dynamic ligand coupling and decoupling of movable liganded nanomaterials to immovable liganded nanoparticles is demonstrated. Dynamic coupling of the movable and immovable ligands promotes integrin binding to the coupled ligands that stimulate focal adhesion, mechanosensing, and differentiation of stem cells, which are inhibited by the decoupling of the movable and immovable ligands.