Details

Autor(en) / Beteiligte

• Shimada, Masaya
• Shirouchi, Bungo
• Kobayashi, Yota
• Higuchi, Mina
• Okumura, Mai
• Nakagawa, Tomoyuki
• Hayakawa, Takashi

Titel

Treatment with Interleukin-25 Suppresses Short-Term High-Fructose Diet-Induced Hepatic Gene Expression and Activities of Fatty Acid Synthesis Enzymes in Rats

Ist Teil von

• Journal of Oleo Science, 2023, Vol.72(1), pp.99-104

Ort / Verlag

Japan: Japan Oil Chemists' Society

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• This study aimed to investigate the effects of interleukin-25, which belongs to the interleukin-17 family, on short-term high-fructose diet-induced hepatic triacylglycerol accumulation. Rats were fed a high-starch (control) or high-fructose diet for 7 d, with or without intraperitoneal administration of recombinant interleukin-25 from days 3-7. Treatment with interleukin-25 significantly reduced the mRNA levels and activity of fatty acid synthesis enzymes and caused a nominal reduction in hepatic triacylglycerol levels in rats fed a high-fructose diet but not in those fed a control diet. Interleukin-25 treatment did not affect the mRNA levels of β-oxidation enzymes in either the control or fructose-fed rats. These results suggest that treatment with interleukin-25 suppresses short-term high-fructose diet-induced fatty acid synthesis and leads to the alleviation of triacylglycerol accumulation in the liver.