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Photoinduced α‐Alkylation of Tetrahydroisoquinolines with Organoboron Reagent Enabled by Organic Photocatalyst
Ist Teil von
European journal of organic chemistry, 2023-02, Vol.26 (6), p.n/a
Ort / Verlag
Weinheim: Wiley Subscription Services, Inc
Erscheinungsjahr
2023
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
We describe an efficient method for α‐functionalization of N‐aryl‐tetrahydroisoquinolines under visible‐light‐irradiation catalyzed by organic photocatalyst. This protocol provides a concise and environmental approach for the rapid allylation and benzylation of N‐aryl‐tetrahydroisoquinolines, and shows broad substrate scope. Stable organoboron reagents have shown their ability in the construction of challenging Csp3−Csp3 bond. The load of the photocatalyst is low and the oxidant is inexpensive and less toxic.
This work disclosed a concise and environmental approach for the rapid alkylation of N‐aryl‐tetrahydroisoquinolines, providing a new route to versatile intermediates of tetrahydroisoquinoline derivatives. Stable organoboron reagents have shown their ability in the photoinduced aerobic cross‐coupling reactions, allowing the construction of challenging Csp3−Csp3 bond.