Details

Autor(en) / Beteiligte

• Li, Mingxi
• Cheng, Xiao
• Chen, Zhe
• Ni, Zhonghua
• Gu, Ning
• Yang, Fang

Titel

Platelet magnetic nanocarriers as MRI sensors to delineate vascular injury network and targeted pre-protection in ischemic stroke

Ist Teil von

• Science China materials, 2023-02, Vol.66 (2), p.827-835

Ort / Verlag

Beijing: Science China Press

Erscheinungsjahr

2023

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• Accurate mapping the damaged vascular network is key to subsquent effective therapeutic strategy implementation in ischemic stroke. In this study, magnetic resonance imaging (MRI) based on a platelet membrane biomimetic magnetic nanocarrier, loaded with L-arginine and γ-Fe 2 O 3 magnetic nanoparticles (PAMNs), has been developed for delineating the vascular injury network in acute ischemic stroke. Due to the loading of γ-Fe 2 O 3 nanoparticles, multi-parameter MRI including T 2 * -weighted imaging (T 2 * WI) and diffusion-weighted imaging (DWI) have been used to localize the stroke lesion and evaluate the severity of damaged vasuclar network, respectively. Results demonstrated that the PAMNs can specifically target to different types of damaged blood vasculature. Based on the PAMNs accumulation in the stroke lesion, T 2 * imaging delineated the damaged vascular injury network, espcially for penumbra. Furthermore, with the L-arginine release in the lesion, the DWI of MRI was applied to evaluate the pre-protection effect. This showed great potential for accurate positioning and real-time monitoring of stroke ischemic lesions. Therefore, the PAMNs-based MRI technique is feasible for vascular obstruction/thrombus location, severity assessment, and real-time monitoring of lesion development in ischemic lesions in the early stage of stroke.