Details

Autor(en) / Beteiligte

• Ponomarev, S. A.
• Shulguina, S. M.
• Kalinin, S. A.
• Antropova, E. N.
• Rykova, M. P.
• Orlova, K. D.
• Kutko, O. V.
• Shmarov, V. A.
• Vlasova, D. D.
• Sadova, A. A.

Titel

State of the Human Innate Immunity Cell Component during 120-Day Isolation in a Pressurized Module

Ist Teil von

• Human physiology, 2022, Vol.48 (7), p.827-832

Ort / Verlag

Moscow: Pleiades Publishing

Erscheinungsjahr

2022

Quelle

SpringerLink

Beschreibungen/Notizen

• Innate immunity was investigated in six volunteers aged 28 to 44 years participating in the experiment with 120-day isolation in a controlled environment. Peripheral blood samples collected during isolation were analyzed to determine the content of monocytes and granulocytes expressing intracellular (TLR3, TLR8, TLR9) and surface (TLR1, TLR2, TLR4, TLR5, TLR6) TLRs, as well as the content of natural killer lymphocytes (CD3 – CD16 + CD56 + ). The system of pattern-recognition receptors of innate immunity cells exhibited heterogenic reaction to isolation with predominant activation throughout the entire experimental exposure. The revealed changes seem to reflect a complex adaptive process that occurs in the human immune system during the establishment of a dynamic balance with extreme environmental factors, including response to endogenous and exogenous immune stimuli.