Details

Autor(en) / Beteiligte

• Sugumaran, Abimanyu
• Sadhasivam, Janani
• Gawas, Pratiksha
• Nutalapati, Venkatramaiah
• Pandian, Rajesh
• Kumar Perumal, Sathish

Titel

Curcumin conjugated dextran coated Fe3O4 Nanoparticles: Cytotoxic effect on lung cancer cell line A549

Ist Teil von

• Materials science & engineering. B, Solid-state materials for advanced technology, 2022-12, Vol.286, p.116047, Article 116047

Ort / Verlag

Lausanne: Elsevier B.V

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] •Curcumin loaded surface coated Fe3O4 magnetic nanoparticles grafted with dextran.•The impacts of the surface coating were correlated with the colloidal property.•High affinity of carboxyl group with positive iron surface confirms dextran layer.•No significant change in magnetization even after dextran coating.•Cytotoxicity tests shows significant cytotoxic effect on A549 cancer cells. Surface coating of Magnetic Nanoparticles (MNPs) plays a key role in the prohibition of agglomeration, improved colloidal stability, and biocompatibility. This research aims to develop and evaluate curcumin-conjugated dextran-coated MNPs for the cytotoxic potential of lung cancer cell A549. Fe3O4 NPs were prepared by a simple co-precipitation method followed by surface coating with dextran. FT-IR, micro Raman, and powder XRD results confirm that functionalization does not alter the crystallinity of Fe3O4 and the particle size varied from ∼ 147–216 nm. The surface morphology of the conjugate shows that the drug-polymer embedded homogeneously over the surface. The in vitro release of the drug shows ∼ 77.80 ± 5.4 % and ∼ 5.15 ± 3.3 % from Cur-Dex-Fe3O4 NPs and curcumin suspension over 24 h. The IC50 value of 22.5 μg/mL with significant changes in the chromatin of cells was observed in the MTT assay and Hoechst 33,528 staining. The developed Cur-Dex-Fe3O4 NPs can effective against the A549 lung cancer cell line.