Details

Autor(en) / Beteiligte

• Gamboa, Pedro
• Sánchez de Vicente, Javier
• Galán, Cristina
• Jáuregui, Ignacio
• Segurola, Aritza
• García‐Lirio, Eduardo
• Seras, Yolanda
• Martínez‐Antón, Mª. Dolores
• Arrien de Lecea, Angel

Titel

Non‐immediate hypersensitivity reactions to iomeprol: Diagnostic value of skin tests and cross‐reactivity with other iodinated contrast media

Ist Teil von

• Allergy (Copenhagen), 2022-12, Vol.77 (12), p.3641-3647

Ort / Verlag

Denmark: Blackwell Publishing Ltd

Erscheinungsjahr

2022

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Background Iodinated contrast media produce non‐immediate hypersensitivity reactions (NIHR). The goal of this prospective study was to determine the utility of skin tests and the subsequent tolerance to negative skin‐tested iodinated contrasts in patients with NIHR caused by iomeprol. Methods Prick and intradermal tests with iomeprol, iopamidol, iopromide, and iobitridol were performed in all patients. IV challenge with the causative contrast (iomeprol in 90%) was made if skin tests were negative. In case of a positive skin test with the causal contrast, or a positive challenge test with it, IV challenge test with an alternative, negative skin‐tested contrast was performed in all patients. Results Skin tests were positive in 47.6% (20/42) of patients with NIHR induced by iomeprol. Of the 66 challenge tests performed with negative skin‐tested iodinated contrasts, tolerance was confirmed in 35 (53%): 32 iomeron, 2 iobitridol, 1 iopamidol. Cross‐reactivity between iomeprol and iopamidol was 22% (4/20 in patients with positive skin tests and 5/21 in patients with negative skin tests). Conclusions Sensitivity of the skin tests was less than 50% NIHRs due to iomeprol, while the negative predictive value of skin tests in patients who tolerated challenges with alternative contrasts (mainly iopamidol) was 53% (35 tolerated out of 66 performed). The cross‐reactivity between iomeprol and iopamidol is high. This study determines the utility of skin tests and the subsequent tolerance to negative skin‐tested ICM in patients with NIHR caused by iomeprol. In iomeprol‐induced NIHR, skin tests sensitivity is less than 50%, though the negative predictive value of skin tests in patients who tolerated alternative contrasts (mainly iopamidol) is 53%. There is a high cross‐reactivity between iomeprol and iopamidol. Abbreviations: ICM, iodinated contrast media; NIHR, non‐immediate hypersensitivity reactions