Details

Autor(en) / Beteiligte

• Kim, Chan Ho
• You, Dong Gil
• E K, Pramod Kumar
• Han, Kyung Hee
• Um, Wooram
• Lee, Jeongjin
• Lee, Jae Ah
• Jung, Jae Min
• Kang, Heegun
• Park, Jae Hyung

Titel

Self-immolative nanosensitizer for glutathione depletion- assisted sonodynamic therapy

Ist Teil von

• Theranostics, 2022, Vol.12 (17), p.7465-7475

Ort / Verlag

Australia: Ivyspring International Publisher Pty Ltd

Erscheinungsjahr

2022

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Despite remarkable advances in sonodynamic therapy (SDT) of cancer, the low reactive oxygen species (ROS) quantum yield of the sonosensitizer remains a critical concern in glutathione (GSH)-overexpressing cancer cells. For enhanced SDT, we report hydrophilized self-immolative polymer (SIP)-decorated TiO nanoparticles (HSIPT-NPs) to achieve on-demand GSH depletion and ROS generation. Upon intracellular delivery of HSIPT-NPs into hydrogen peroxide-rich cancer cells, SIP is degraded through electron transfer to produce GSH-depleting quinone methide, reprogramming GSH cancer cells into GSH phenotype. In the presence of ultrasound, compared to conventional TiO NPs, HSIPT-NPs induce significantly higher oxidative stress to cancer cells by incapacitating their antioxidant effects. SDT with HSIPT-NPs effectively inhibit tumor growth in mice via the synergistic effects of GSH depletion and ROS generation. On the basis of their ability to reprogram cancer cells, HSIPT-NPs offer considerable potential as a nanosensitizer for enhanced SDT.