Details

Autor(en) / Beteiligte

• Hu, Zhi‐Chao
• Cui, Jing‐Jing
• Dong, Zhi‐Bing

Titel

An Efficient Synthesis of Thioesters Starting from N‐Arylthiocarbamates and Indoles: A Newman‐Kwart‐Type Rearrangement

Ist Teil von

• European journal of organic chemistry, 2022-11, Vol.2022 (42), p.n/a

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An efficient method for synthesizing thioester compounds under metal‐free conditions was reported. Thus, a series of indole‐substituted thioesters were easily obtained in the presence of PhICl2 (dichloroiodo‐benzene) starting from N‐arylthiocarbamates and indoles. This Newman‐Kwart‐type rearrangement reaction features metal free, base free, mild reaction conditions, good functional tolerance, and good yield, showing potential value for preparing some biologically and pharmaceutically active compounds. In the presence of PhICl2, a series of thioester compounds containing indole structures were obtained starting from indoles and the masked thiols (N‐arylthiocarbamates). This method has the advantage of easily available starting material, metal and base‐free, simple operation, mild reaction conditions, and produces good yields.