Details

Autor(en) / Beteiligte

• Zhang, Qisi
• Kounde, Cyrille S
• Mondal, Milon
• Greenfield, Jake L
• Baker, Jennifer R
• Kotelnikov, Sergei
• Ignatov, Mikhail
• Tinworth, Christopher P
• Zhang, Leran
• Conole, Daniel
• De Vita, Elena
• Kozakov, Dima
• McCluskey, Adam
• Harling, John D
• Fuchter, Matthew J
• Tate, Edward W

Titel

Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

Ist Teil von

• Chemical communications (Cambridge, England), 2022-09, Vol.58 (78), p.1933-1936

Ort / Verlag

Cambridge: Royal Society of Chemistry

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light. A new class of arylazopyrazole photoswitchable PROTACs (AP-PROTACs) enables light-triggered degradation of a specific ensemble of protein kinases.