Details

Autor(en) / Beteiligte

• Zhang, Huimin
• Tang, Weina
• Gong, Qi
• Yang, Xinyi
• Sun, Yunqiang
• Dai, Zhichao
• Hu, Zunfu
• Zheng, Xiuwen

Titel

A dual gate-controlled intelligent nanoreactor enables collaborative precise treatment for cancer nanotherapy

Ist Teil von

• Nanoscale, 2022-09, Vol.14 (36), p.13113-13122

Ort / Verlag

Cambridge: Royal Society of Chemistry

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Recently, disulfiram (DSF), approved by the FDA as an anti-alcoholic drug, has been proved as an effective antitumor drug after chelating with Cu 2+ . To overcome the shortage of intracellular Cu 2+ , we have constructed a dual gate-controlled intelligent nanoreactor (HA-DSF@HCuS@FePtMn, HDHF) via the ingenious combination of hollow copper sulfide (HCuS) nanoparticles, DSF and FePtMn nanocrystals. HDHF has a NIR-actuated gate and enzyme-actuated gate that could be opened in the hyaluronidase-abundant tumor microenvironment with NIR laser irradiation to trigger drug (DSF/FePtMn) release and synergistic therapy. Moreover, the FePtMn nanocrystals could continuously release Fe 2+ , which could catalyze H 2 O 2 into highly cytotoxic hydroxyl radicals (&z.rad;OH), triggering chemodynamic therapy (CDT). When exposed to NIR laser, HCuS could collapse and release Cu 2+ , which could immediately chelate with DSF, forming the effective anticancer drug (Cu(DTC) 2 ) and enabling DSF-based chemotherapy. More importantly, the efficient photothermal therapy (PTT) effect of HCuS could accelerate the FePtMn-based CDT and the release of Cu 2+ /DSF, improving tumor treatment efficiency. Thus, this study represents a distinctive paradigm of a dual gate-controlled intelligent nanoreactor enabled PTT-augmented DSF-based chemotherapy and FePtMn-based CDT for cancer nanotherapy. We have constructed a dual gate-controlled intelligent nanoreactor (HA-DSF@HCuS@FePtMn, HDHF) by the ingenious combination of hollow copper sulfide nanoparticles (HCuS), DSF and FePtMn nanocrystals.