Details

Autor(en) / Beteiligte

• Tram, Le Huyen
• Van Thong, Nguyen
• Thuy, Le Thi
• Anh, Nguyen Tuan
• Minh, Nguyen Hoang
• Minh, Tran Thi
• Thi Hong Phuong, Nguyen
• Ha, Tran Thu
• Nguyet Nguyen, Thi Minh
• Le, Duc Dat
• Hiep, Nguyen Dinh
• Park, Jong-Tae
• Thi To Chinh, Truong
• Thu Huong, Tran
• Lee, Mina

Titel

Secondary metabolites from Valeriana jatamansi with their anti-inflammatory activity

Ist Teil von

• Natural product research, 2022-09, Vol.36 (18), p.4614-4623

Ort / Verlag

Abingdon: Taylor & Francis

Erscheinungsjahr

2022

Quelle

Taylor & Francis

Beschreibungen/Notizen

• Valeriana jatamansi is hired as multiple remedies for treatment of insomnia, blood and circulatory disorders, asthma, dry cough, jaundice, seminal weakness, cardiac debility, and skin diseases in Vietnam. Our research discovered the phytochemical investigation of constituents from this herbal medicine resulted in the isolation of two new compounds (jatamansides A (4) and B (7)) together with 16 known ones from the whole plant. Their structures were established by using spectroscopic techniques (multinuclear and multidimensional nuclear magnetic resonance, infrared, ultraviolet-visible), mass spectrometry, hydrolysis analysis, or comparing their NMR data to those reported in the literature. In addition, all the isolates were evaluated for their inhibitory effect against TNF-α production in LPS-stimulated on RAW264.7 cells with significant inhibition.