Details

Autor(en) / Beteiligte

• Tomás, António Miguel Maia Domingues Carvalho

Titel

The Neurobiology of Binge Eating

Ort / Verlag

ProQuest Dissertations & Theses

Erscheinungsjahr

2019

Link zum Volltext

• ProQuest

Quelle

ProQuest Dissertations & Theses A&I

Beschreibungen/Notizen

• Binge eating is a recent diagnosis, firstly coded in the fifth edition of the Diagnostic and Statistical Manual of Mental disorders (DSM-5) in 2013. It is characterized by overeating behavior associated to the sense of lack of control, causes marked distress in the individual and has an estimated life-prevalence of 0,85-1,4%. In this article we review the main neurobiological mechanisms underlying this condition. Several studies found associations between binge eating and the dysregulation of the opioidergic and dopaminergic systems. This dysregulation leads to altered hedonic responses to food cues, reward sensitivity changes, and differences in general consumption of food. Orexin, nociceptin/orphanin FQ and oxytocin systems also appear to be involved in the expression of binge eating behavior. Therefore, binge eating behavior might be associated to altered function of mu-opioid receptor in Nucleus Accumbens and disturbances of striatal dopamine receptors D1 and D2. Other neurotransmitters, such as nociceptin/orphanin FQ, orexin and oxytocin have also been implicated. Future binge eating pharmacological therapies might target these neuronal substrates.