Details

Autor(en) / Beteiligte

• Kinoshita, Yoshihisa
• Kuratsukuri, Katsuyuki
• Landas, Steve
• Imaida, Katsumi
• Rovito, Peter M.
• Wang, Ching Y.
• Haas, Gabriel P.

Titel

Expression of Prostate‐Specific Membrane Antigen in Normal and Malignant Human Tissues

Ist Teil von

• World journal of surgery, 2006-04, Vol.30 (4), p.628-636

Ort / Verlag

New York: Springer‐Verlag

Erscheinungsjahr

2006

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• Background Prostate‐specific membrane antigen (PSMA) is upregulated in androgen‐dependent prostate carcinoma and it has been targeted for immunotherapy and diagnosis of this cancer. However, this protein is also expressed in other tissues. The objective of this study is to investigate its expression in normal and malignant human tissues. Methods Using monoclonal antibodies 24.4E6 (specific for residues 638–657) and 7E11.C5 (specific for the transmembrane domain of PSMA), immunohistochemical detection of PSMA was performed in surgical specimens. Results Prostate‐specific membrane antigen was detected in the epithelium of prostate, urinary bladder, proximal tubules of kidney, liver, esophagus, stomach, small intestine, colon, breast, fallopian tubes and testicular seminiferous tubules, hippocampal neurons and astrocytes, ependyma, cortex and medulla of the adrenal gland, and ovary stroma. It was also detected in neoplasms of the prostate, kidney, urinary bladder, stomach, small intestine, colon, lung, adrenal gland, and testis. It was not detected in normal seminal vesicles or the lung. Conclusions These findings demonstrate that PSMA is widely distributed in normal tissues, and, depending on the tumors, its expression is up‐ or down‐regulated, or unchanged. The broad distribution of PSMA may make it suitable for the diagnosis and therapy of a wide variety of tumors.