Details

Autor(en) / Beteiligte

• Ran, Ruilong
• Peng, Yan
• Xiao, Lang
• Wang, Yanlai
• Zhang, Tonghua
• Liu, Zhongwen
• Li, Zhi

Titel

Fabrication of antimicrobial poly(lactic‐co‐glycolic acid)/silk fibroin/aloe anthraquinone fibrous membranes for potential application of wound healing

Ist Teil von

• Journal of applied polymer science, 2022-07, Vol.139 (25), p.n/a

Ort / Verlag

Hoboken, USA: John Wiley & Sons, Inc

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Antibacterial wound dressings can kill bacteria around the wound and then accelerate the wound healing. To fabricate an antibacterial membrane for potential application of wound healing, poly(lactic‐co‐glycolic acid) (PLGA), silk fibroin (SF), and natural antimicrobial agent aloe anthraquinone (AA) were blended for electrospinning. The electrospun PLGA/SF/AA fibrous membrane consists of smooth and uniform fibers with an average diameter of 583 ± 112 nm. The stress of the PLGA/SF/AA fibrous membrane is 3.88 ± 0.34 MPa, which can ensure its application in skin wound healing. Owing to the good hydrophilicity of blended SF, PLGA/SF/AA fibrous membrane can release 47% of AA at 48 h and 62% of AA in 15 days. PLGA/SF/AA membrane also exhibits good antimicrobial properties and cell compatibility. These results indicate that the fabricated PLGA/SF/AA fibrous membrane in this study has a good application potential for wound healing. Preparation process of PLGA/SF/AA fibrous membrane and potential wound healing effect. Fresh aloe vera was extracted and frozen drying into powder. The regenerated SF was prepared from Bombyx mori cocoons. Poly (lactic‐co‐glycolic acid) (PLGA), silk fibroin (SF) and natural antimicrobial agent aloe anthraquinone (AA) were blended for electrospinning. The electrospun PLGA/SF/AA fibrous membrane consists of the smooth and uniform fibers, and exhibit good antimicrobial property and cell compatibility.