Details

Autor(en) / Beteiligte

• Teng, Yaoshu
• He, Hanyi
• Wang, Hongmei
• Lu, Yueyue
• Wang, Xinlu
• Li, Yong
• Lin, Zhihong
• Jain, Deepak Kumar
• Deepak Kumar Jain

Titel

Two Potential Biomarkers for the Diagnosis and Prognosis of Laryngeal Carcinoma: CCL20 and IL-17A

Ist Teil von

• Wireless communications and mobile computing, 2022-04, Vol.2022, p.1-6

Ort / Verlag

Oxford: Hindawi

Erscheinungsjahr

2022

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• This study is to uncover the possibilities of CCL20 and IL-17A to be potential hallmarks for laryngeal carcinoma. Relative levels of CCL20 and IL-17A in laryngeal carcinoma tissues were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Correlation between CCL20 and IL-17A was analyzed by Pearson correlation test. Receiver operating characteristic (ROC) curves were depicted for assessing diagnostic values of CCL20 and IL-17A in laryngeal carcinoma. In addition, 98 laryngeal carcinoma patients were followed up for 5 years. Their follow-up data were utilized for assessing prognostic values of CCL20 and IL-17A. CCL20 and IL-17A were upregulated in laryngeal carcinoma tissues than those of normal ones. ROC curves identified diagnostic values of CCL20 (AUC=0.9719, cutoff value=4.86, sensitivity=98.98%, specificity=87.76%) and IL-17A (AUC=0.7965, cutoff value=3.39, sensitivity=71.31%, specificity=71.52%) in laryngeal carcinoma. Worse prognosis was observed in laryngeal carcinoma patients expressing high level of CCL20 or IL-17A. CCL20 and IL-17A are upregulated in laryngeal carcinoma tissues, which are unfavorable factors for the prognosis of laryngeal carcinoma. CCL20 and IL-17A are promising hallmarks of laryngeal carcinoma.