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An Efficient and Simple Breast Milk Sample Preparation to Detect Polycyclic Aromatic Hydrocarbons by Gas Chromatography-Mass Spectrometry
Ist Teil von
Journal of analytical chemistry (New York, N.Y.), 2022-04, Vol.77 (4), p.513-518
Ort / Verlag
Moscow: Pleiades Publishing
Erscheinungsjahr
2022
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Polycyclic aromatic hydrocarbons (
PAHs
) can be extremely hazardous to human health due to their carcinogenicity and toxicity. Following mother exposure, a part of PAHs might be transferred into breast milk, and PAH exposure may results in adverse effects in breastfeeding infants. Chrysene, benzo(a,h)anthracene, benzo(b)fluoranthene and benzo(a)pyrene (
PAH4
) are the most suitable indicators of PAHs in food. The aim of this work was to develop a sensitive and selective sample preparation method for the determination of PAH4 in breast milk using gas chromatography-mass spectrometry. The study compared different extraction methods of PAHs. The method was validated using parameters such as linearity, precision, accuracy, limit of detection (
LOD
) and limit of quantification (
LOQ
). The calibration curve was linear over the range of 0.5–50 ng/mL. The intra- and inter-day relative standard deviation values were less than 0.37%. The recovery values ranged between 99.97 and 99.99%. The LOD and LOQ values were found to be between 1.4 and 1.7 ng/mL and between 2.5 and 4 ng/mL, respectively.