Bone marrow transplantation (Basingstoke), 2005-12, Vol.36 (11), p.1001-1008
2005
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- Autor(en) / Beteiligte
- Titel
- Adenovirus infection rates in pediatric recipients of alternate donor allogeneic bone marrow transplants receiving either antithymocyte globulin (ATG) or alemtuzumab (Campath)
- Ist Teil von
- Bone marrow transplantation (Basingstoke), 2005-12, Vol.36 (11), p.1001-1008
- Ort / Verlag
- Basingstoke: Nature Publishing Group
- Erscheinungsjahr
- 2005
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Infectious complications due to adenovirus are of increasing concern after allogeneic stem cell transplantation. Over the past 4 years, we have modified our conditioning regimens to use alemtuzumab in preference to anti-thymocyte globulin (ATG) for pediatric patients receiving stem cell transplants from alternate donors. Recent reports in adult studies implicate alemtuzumab as a risk factor for adenovirus infection. We therefore evaluated the incidence of adenovirus infection in pediatric patients receiving either ATG or alemtuzumab in their conditioning regimens. Of the 111 patients evaluated, a total of 54 patients received ATG and 57 patients received alemtuzumab. In total, 35/111 (32%) patients were infected by adenovirus, and 9/111 (8%) had adenovirus disease (AD). Adenovirus infection was greater in the alemtuzumab group than the ATG group (23/57 vs 12/54) (P=0.039) and disseminated AD was more frequent in the alemtuzumab group vs the ATG group (8/57 and 1/54 respectively) (P=0.032). The presence of Grade 3-4 graft-versus-host disease was a risk factor for adenovirus infection. Our findings highlight the fact that adenovirus infection is a frequent complication after stem cell transplantation from alternate donors in the pediatric population and that alemtuzumab increases the risk of infection compared to ATG. This work will help in identifying at-risk populations for our upcoming immunotherapy trial using adoptively transferred donor-derived adenovirus-specific cytotoxic T lymphocytes.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0268-3369eISSN: 1476-5365DOI: 10.1038/sj.bmt.1705164Titel-ID: cdi_proquest_journals_2642179295
- Format
- –
- Schlagworte
- Adenovirus, Adenovirus diseases, Adenovirus Infections, Human - chemically induced, Adenovirus Infections, Human - etiology, Adenoviruses, Adolescent, Alemtuzumab, Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy, Antibodies, Monoclonal - administration & dosage, Antibodies, Monoclonal - toxicity, Antibodies, Monoclonal, Humanized, Antibodies, Neoplasm - administration & dosage, Antibodies, Neoplasm - toxicity, Antilymphocyte serum, Antilymphocyte Serum - administration & dosage, Biological and medical sciences, Bone marrow, Bone marrow transplantation, Bone Marrow Transplantation - adverse effects, Bone Marrow Transplantation - methods, Bone marrow, stem cells transplantation. Graft versus host reaction, Child, Child, Preschool, Complications, Complications and side effects, Conditioning, Cytotoxicity, Diagnosis, Drug therapy, Globulins, Graft vs Host Disease - complications, Graft-versus-host reaction, Health risks, Hematologic and hematopoietic diseases, Hematologic Diseases - complications, Hematologic Diseases - therapy, Humans, Immunotherapy, Incidence, Infant, Infections, Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis, Lymphocytes, Lymphocytes T, Medical sciences, Monoclonal antibodies, Patients, Pediatrics, Retrospective Studies, Risk analysis, Risk Factors, Stem cell transplantation, Stem cells, Thymocytes, Tissue Donors, Transfusions. Complications. Transfusion reactions. Cell and gene therapy, Transplantation, Transplantation Conditioning - adverse effects, Transplantation Conditioning - methods, Transplantation, Homologous, Transplants