Details

Autor(en) / Beteiligte

• Wu, Bo
• Yeasmin, Sanjida
• Liu, Ye
• Cheng, Li-Jing

Titel

Sensitive and selective electrochemical sensor for serotonin detection based on ferrocene-gold nanoparticles decorated multiwall carbon nanotubes

Ist Teil von

• Sensors and actuators. B, Chemical, 2022-03, Vol.354, p.131216, Article 131216

Ort / Verlag

Lausanne: Elsevier B.V

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Serotonin, or 5-hydroxytryptamine (5-HT), is a neurotransmitter that plays a crucial role in neural activities. 5-HT deficiency is clinically related to several psychiatric disorders. Therefore, sensitive 5-HT detection is critical in the diagnosis of diseases associated with neurological disorders. Here we developed a sensitive electrochemical sensor utilizing ferrocene covalently linked gold nanoparticles on multiwall carbon nanotubes (FeC-AuNPs-MWCNT), electrocatalytic nanocomposites, to enhance 5-HT detection. FeC-AuNPs-MWCNT modified screen-printed carbon electrodes (SPCEs) provide catalytic activity towards 5-HT oxidation from both FeC and AuNPs along with the high conductance from the carbon nanotube network. The FeC-AuNPs-MWCNT was synthesized by chemically reducing AuNPs on MWCNT surfaces and covalently attaching FeC to the AuNPs. Square wave voltammetry analyses confirmed that the electrocatalytic nanocomposite modified electrodes improved the electrocatalytic activity towards 5-HT oxidation, 61 times higher than the unmodified SPCE. The sensor exhibited a sensitive response to 5-HT over a wide dynamic range from 0.05 µM to 20 µM, a limit of detection of 17 nM (S/N = 3), excellent reproducibility, and high selectivity towards 5-HT against several interferers, including ascorbic acid, urea, uric acid, dopamine, and glucose. The sensor was successfully demonstrated to detect sub-µM 5-HT in urine samples with satisfactory recoveries (98.3–104.9%) and a low relative standard deviation of less than 3%. This sensitive, selective, and cost-effective electrochemical sensor shows great promise in direct 5-HT analysis for clinical applications. •Ferrocene-gold decorated carbon nanotubes promote electro-oxidation of serotonin.•Catalytic nanocomposite improves electron transfers and conductance of electrode.•The serotonin sensor exhibits excellent selectivity against other metabolites.•The sensor successfully detects the serotonin in urine samples with high recoveries.