Details

Autor(en) / Beteiligte

• Bozuyuk, Ugur
• Suadiye, Eylul
• Aghakhani, Amirreza
• Dogan, Nihal Olcay
• Lazovic, Jelena
• Tiryaki, Mehmet Efe
• Schneider, Martina
• Karacakol, Alp Can
• Demir, Sinan Ozgun
• Richter, Gunther
• Sitti, Metin

Titel

High‐Performance Magnetic FePt (L10) Surface Microrollers Towards Medical Imaging‐Guided Endovascular Delivery Applications

Ist Teil von

• Advanced functional materials, 2022-02, Vol.32 (8), p.n/a

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc

Erscheinungsjahr

2022

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Controlled microrobotic navigation in the vascular system can revolutionize minimally invasive medical applications, such as targeted drug and gene delivery. Magnetically controlled surface microrollers have emerged as a promising microrobotic platform for controlled navigation in the circulatory system. Locomotion of micrororollers in strong flow velocities is a highly challenging task, which requires magnetic materials having strong magnetic actuation properties while being biocompatible. The L10‐FePt magnetic coating can achieve such requirements. Therefore, such coating has been integrated into 8 µm‐diameter surface microrollers and investigated the medical potential of the system from magnetic locomotion performance, biocompatibility, and medical imaging perspectives. The FePt coating significantly advanced the magnetic performance and biocompatibility of the microrollers compared to a previously used magnetic material, nickel. The FePt coating also allowed multimodal imaging of microrollers in magnetic resonance and photoacoustic imaging in ex vivo settings without additional contrast agents. Finally, FePt‐coated microrollers showed upstream locomotion ability against 4.5 cm s−1 average flow velocity with real‐time photoacoustic imaging, demonstrating the navigation control potential of microrollers in the circulatory system for future in vivo applications. Overall, L10‐FePt is conceived as the key material for image‐guided propulsion in the vascular system to perform future targeted medical interventions. FePt (L10) film‐coated magnetic surface microrollers outperform the previous ones with other magnetic films during surface locomotion against the fluidic flow direction. They also exhibit high imaging contrast during magnetic resonance and photoacoustic medical imaging‐based tracking of the microrollers in ex vivo settings and high biocompatibility with macrophages and endothelial cells in vitro.