Details

Autor(en) / Beteiligte

• Goncharov, A. G.
• Yurova, K. A.
• Shupletsova, V. V.
• Gazatova, N. D.
• Melashchenko, O. B.
• Litvinova, L. S.

Titel

Characteristics of Umbilical-Cord Blood and Its Use in Clinical Practice

Ist Teil von

• Cell and tissue biology, 2022-02, Vol.16 (1), p.15-31

Ort / Verlag

Moscow: Pleiades Publishing

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• This paper provides a brief description of the components of umbilical-cord blood (CB). It consider the application of CB and its components, more specifically, mesenchymal stem cells, in experimental biology and medicine to activate the regeneration of organs and tissues, as part of complex measures for the treatment of chronic diseases of various origin (blood diseases and primary immunodeficiencies, neurodegenerative diseases, myocardial infarction, obesity, diabetes mellitus, liver cirrhosis, immune-dependent and autoimmune pathologies, etc.). The review also considers the use of CB serum (plasma) in postoperative recovery for the treatment of eye and neurodegenerative diseases and age-related changes. The possibility of using CB to enrich culture media for the growth of various cell cultures employed in regenerative medicine is described. The importance and necessity of standardization of methods for obtaining CB and its components, their testing and routes of administration, and regulations for the use of CB and its components in clinical practice is emphasized. The review focuses on the use of CB and its components in experimental biology to model the processes of reparation and regeneration of tissues and organs in model animals.