Details

Autor(en) / Beteiligte

• Lane, Ciaran
• Myers, Candace
• Jiang, Deping
• Cooke, Andrew
• Kerr, Paul

Titel

Selected functional outcomes in advanced oral cancer: Comparison of surgery alone versus surgery with postoperative radiotherapy

Ist Teil von

• Head & neck, 2022-03, Vol.44 (3), p.710-721

Ort / Verlag

Hoboken, USA: John Wiley & Sons, Inc

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Wiley Online Library Core Title

Beschreibungen/Notizen

• Background Study objectives were to determine whether the addition of postoperative radiation (PORT) resulted in a decline in oral function relative to surgery alone and to describe the longitudinal course of oral function following treatment of advanced oral cancer. Methods This was a 36‐month retrospectively analyzed observational cohort study of patients with stage III‐IV oral cancer. Prospectively collected, oral functional outcomes were acquired pretreatment and 3, 6, 12, 24, and 36 months post‐treatment. Results One hundred and eighteen patients were included. Forty‐three patients treated with surgery alone were compared to 75 who received surgery with PORT. Mixed model analysis demonstrated the acute effect of PORT was associated with patient‐rated xerostomia (p < 0.001) and the late or persistent effect was associated with decreased clinician‐rated eating in public (p = 0.008), understandability of speech (p = 0.02), and normalcy of diet (p = 0.005) compared with surgery alone. There were no differences between surgery alone and PORT groups in clinician‐rated feeding tube dependence or patient‐rated speech handicap. Conclusions The use of PORT was associated with a demonstrable decline in oral function in four of six outcomes measures relative to surgery alone.