Details

Autor(en) / Beteiligte

• Wu, Chih‐Yu
• Murugan, Sivan Perumal
• Wang, Yu‐Wei
• Pan, Hao‐Wei
• Sun, Bing‐Jian
• Lin, Yu‐Ting
• Fatimah, Siti
• Chang, Agnes H. H.
• Chen, Chinpiao
• Lee, Gene‐Hsian

Titel

Synthesis of Indoline‐Fused 2,5‐Diketopiperazine Scaffolds via Ugi‐4CR in the Basic Mediated Tandem Consecutive Cyclization

Ist Teil von

• Advanced synthesis & catalysis, 2021-11, Vol.363 (21), p.4960-4968

Ort / Verlag

Heidelberg: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• This study has developed a method to prepare diastereo‐ and regio‐selective indoline‐fused 2,5‐diketopiperazine scaffolds. The synthetic process involved an Ugi four‐component reaction in which readily available starting materials were used and a metal‐free intramolecular post‐Ugi tandem consecutive 5‐exo‐trig/6‐exo‐dig cyclization under basic conditions. The plausible mechanism and substrate structures were elucidated by single‐crystal X‐ray diffraction analysis and supported by density functional theory calculations.