Details

Autor(en) / Beteiligte

• Lu, Shu‐Ning
• Yang, Hefei
• Zhang, Jiajun
• Chen, Zhengkai
• Wu, Xiao‐Feng

Titel

Oxidative Cyclization of Trifluoroacetimidohydrazides with D‐Glucose for the Metal‐Free Synthesis of 3‐Trifluoromethyl‐1,2,4‐Triazoles

Ist Teil von

• Advanced synthesis & catalysis, 2021-11, Vol.363 (21), p.4982-4987

Ort / Verlag

Heidelberg: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Quelle

Wiley Online Journals

Beschreibungen/Notizen

• A metal‐free oxidative cyclization of readily available trifluoroacetimidohydrazides with D‐glucose for the assembly of 3‐trifluoromethyl‐1,2,4‐triazoles has been disclosed. D‐glucose is applied as C1 synthon to provide methine source in the reaction. Control experiments have been conducted to shed light on the reaction mechanism. The synthetic utility of the protocol has been explored by the implementation of scale up reaction and the synthesis of the key skeleton of NKI‐receptor ligand.