Details

Autor(en) / Beteiligte

• Lee, Junmin
• Wang, Yonggang
• Xue, Chengbin
• Chen, Yi
• Qu, Moyuan
• Thakor, Jai
• Zhou, Xingwu
• Barros, Natan Roberto
• Falcone, Natashya
• Young, Patric
• van den Dolder, Floor W
• Lee, KangJu
• Zhu, Yangzhi
• Cho, Hyun-Jong
• Sun, Wujin
• Zhao, Bo
• Ahadian, Samad
• Jucaud, Vadim
• Dokmeci, Mehmet R
• Khademhosseini, Ali
• Kim, Han-Jun

Titel

pH-Responsive doxorubicin delivery using shear-thinning biomaterials for localized melanoma treatment

Ist Teil von

• Nanoscale, 2022-01, Vol.14 (2), p.35-36

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Injectable shear-thinning biomaterials (STBs) have attracted significant attention because of their efficient and localized delivery of cells as well as various molecules ranging from growth factors to drugs. Recently, electrostatic interaction-based STBs, including gelatin/LAPONITE® nanocomposites, have been developed through a simple assembly process and show outstanding shear-thinning properties and injectability. However, the ability of different compositions of gelatin and LAPONITE® to modulate doxorubicin (DOX) delivery at different pH values to enhance the effectiveness of topical skin cancer treatment is still unclear. Here, we fabricated injectable STBs using gelatin and LAPONITE® to investigate the influence of LAPONITE®/gelatin ratio on mechanical characteristics, capacity for DOX release in response to different pH values, and cytotoxicity toward malignant melanoma. The release profile analysis of various compositions of DOX-loaded STBs under different pH conditions revealed that lower amounts of LAPONITE® (6NC25) led to higher pH-responsiveness capable of achieving a localized, controlled, and sustained release of DOX in an acidic tumor microenvironment. Moreover, we showed that 6NC25 had a lower storage modulus and required lower injection forces compared to those with higher LAPONITE® ratios. Furthermore, DOX delivery analysis in vitro and in vivo demonstrated that DOX-loaded 6NC25 could efficiently target subcutaneous malignant tumors via DOX-induced cell death and growth restriction. Injectable shear-thinning biomaterials (STBs) have attracted significant attention because of their efficient and localized delivery of cells as well as various molecules ranging from growth factors to drugs.