Journal of antibiotics, 2017-11, Vol.70 (11), p.1043-1046
2017
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Details
- Autor(en) / Beteiligte
- Titel
- Hymerhabdrin A, a novel diterpenoid with antifouling activity from the intertidal sponge Hymerhabdia sp
- Ist Teil von
- Journal of antibiotics, 2017-11, Vol.70 (11), p.1043-1046
- Ort / Verlag
- Japan: Nature Publishing Group
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Hymerhabdrin A (1), a diterpenoid possessing a novel 6/6/5 fused-ring skeleton, together with four known sterols were isolated from an intertidal marine sponge Hymerhabdia sp. Their structures were elucidated by extensive spectroscopic methods, and the relative and absolute configurations of 1 were determined by NOESY analysis and electronic circular dichrosim calculations, respectively. Hymerhabdrin A (1) exhibited significant antifouling activity against Balanus amphitrite larval with LC (lethal concentration 50) value of 3.6 μg ml .
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-8820eISSN: 1881-1469DOI: 10.1038/ja.2017.109Titel-ID: cdi_proquest_journals_2615530767
- Format
- –
- Schlagworte
- Animals, Antibiotics, Antifouling, Antifouling substances, Biofouling - prevention & control, Carbon, Circular Dichroism - methods, Diterpenes, Diterpenes - chemistry, Diterpenes - isolation & purification, Diterpenes - pharmacology, Hymerhabdia, Lethal Dose 50, Magnetic Resonance Spectroscopy - methods, Porifera - chemistry, Spectrum Analysis - methods, Sterols, Sterols - chemistry, Sterols - isolation & purification, Thoracica - drug effects